AUSTIN, Texas — By altering the genetic code in bacteria, researchers at The University of Texas at Austin have demonstrated a method to make therapeutic proteins more stable, an advance that would improve the drugs' effectiveness and convenience, leading to smaller and less frequent doses of medicine, lower health care costs and fewer side effects for patients with cancer and other diseases.
The results were published today in the journal Nature Biotechnology.
Many drugs commonly used to treat cancer and diseases of the immune system — including insulin, human growth hormone, interferon and monoclonal antibodies — can have a short active life span in the human body. That's because these drugs, which are proteins or chains of amino acids linked together by chemical bonds, contain the amino acid cysteine, which makes chemical bonds that break down in the presence of certain compounds found in human cells and blood.
Read the full post at UT News.